Skrill is accepted by over 100 million merchants worldwide including eBay, PayPal, Amazon and many others, though its focus is the facilitation of gaming and online trading.

Major credit and debit card issuers such as Visa, Mastercard, and Maestro are of course supported by Skrill. Customers can also opt to make a bank transfer if preferred. Skrill's Rapid Transfer is an instant bank transfer solution.